Daphne Genkwa Sieb. et Zucc. Water-Soluble Extracts Act on Enterovirus 71 by Inhibiting Viral Entry

Daphne Genkwa Sieb. et Zucc. Water-Soluble Extracts Act on Enterovirus 71 by Inhibiting Viral Entry

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Dried flowers of Daphne genkwa Sieb.et Zucc.(Thymelaeaceae) are a Chinese herbal Suspension Strut Pin medicine used as an abortifacient with purgative, diuretic and anti-inflammatory activities.However, the activity of this medicine against enteroviral infections has not been investigated.

The water-extract of dried buds of D.genkwa Sieb.et Zucc.(DGFW) was examined against various strains of enterovirus 71 (EV71) by neutralization assay, and its initial mode of action was characterized by time-of-addition assay followed by attachment and penetration assays.

Pretreatment of DGFW Mushroom products with virus abolished viral replication, indicating that DGFW inhibits EV71 by targeting the virus.GFW exerts its anti-EV71 effects by inhibiting viral entry without producing cytotoxic side effects and thus provides a potential agent for antiviral chemotherapeutics.